Natural and Non Toxic Alternative to Depression Treatment

Benefits of SAMe

  • Elevates levels of mood-boosting enzymes serotonin and dopamine
  • Enhances adenosine triphosphate (ATP), a renowned energy enhancer
  • Regulates wakefulness in harmony with melatonin, the sleep regulator
  • Shown to be as effective as many synthetic prescription treatments

SAMe the energy and well-being supplement

SAMe is the natural, non-toxic alternative to traditional depression treatments. It's now one of the most sought-after well-being agents on the market because it's bioidentical and gets to work in a matter of days, not weeks.

A naturally occurring compound

SAMe is short for S-adenosyl-L-methionine, a compound produced throughout the body1 . It plays a crucial role in energizing and metabolizing chemical reactions and has a key part in the creation of the 'energy of life' molecule ATP.

SAMe is found in particularly high concentrations in the liver — as such it's used widely as a treatment for various liver conditions. It's also known as the day-time alertness hormone, as it's a major factor in keeping us awake and energized during daylight hours. In this way, it works in tandem with melatonin — the hormone that makes us drowsy as night falls.

A popular supplement

SAMe is widely renowned as the safest and most effective treatment for the alleviation depression you can obtain without a prescription. This is because of two key agents — the first is ATP, which stores and releases all the energy your body needs. The second is methionine, an amino acid long recognized as a potent antioxidant.

Refined over numerous clinical trials since the 1970s, SAMe has come to be harnessed as an agent of 'methylation', a process that provides neurotransmitters with a continual supply of proteins, DNA, and other vital sustenance2 . It has proved to be particularly effective in the brain, as it increases levels of serotonin and dopamine — the two neurotransmitters that control mood and brain function. Keeping levels of SAMe high boosts alertness, memory, and mental wellbeing, while reducing stress and anxiety and SAMe supplements have become popular and sought after. Keep your mind and your mood at their peak with the powerful natural properties of SAMe.

Because SAMe is a sensitive compound to ensure it has maximum effectiveness, our product contains the correct enteric coated tablets which are protected from light.

Note: This supplement should not be combined with prescription antidepressants, nor used by those with bi-polar disorders.


  1. 1. S-adenosyl-L-methionine (SAMe): an introduction. NCCAM.National Center for Complementary and Alternative Medicine, Aug. 2013. Web. 22 May 2014.
  2. 2. Bottiglieri, Teodoro. S-adenosyl-L-methionine (SAMe): from the bench to the bedside—molecular basis of a pleiotrophic molecule. Am J Clin Nutr. 2002;76(5):1151S-1157S.


Samyr – the anti depressant that’s got the power to lift and energise

The remarkable supplement Samyr is a natural route to better moods, increased energy and improved overall brain health.

Working much faster than traditional anti depressants, Samyr act as a powerful aid to ‘feel good’ neurotransmitters serotonin and dopamine. Its key ingredient S-Adenosyl-Methionine plays a role in overall cell energy by assisting the production of ATP (Adenosine triphosphate) – the power house of cells. Not only does it promote regeneration of cells and acts as an antioxidant, it’s a precursor to the methylation process.

Samyr helps trigger the series of reactions in methylation, which takes place to help the body regenerate cells. Although we produce the valuable components that trigger methylation, by taking a supplement such as Samyr or donamet, we’re effectively speeding up regeneration. In fact, low methyl levels are consistent with depression, so if we up them, we can stave off feelings of depression.

Samyr 500mg is designed as an all-round health and brain enhancing supplement. It may come under the name Samyr donamet, or SAMe (donamet), but the results are the same – energy and lift in body and mind.


One 400-mg bottle of lyophilised powder contains: ademetionine (S-Adenosyl-L-Methionine), 1.4-butanedisulfonate, 760 mg equal to 400 mg. One phial of solvent solution contains: water for injectable solutions, L-lysine, sodium hydroxide. One 400-mg gastro-resistant tablet contains: ademetionine (S-Adenosyl-L-Methionine) 1.4-butanedisulfonate, 760 mg equal to 400 mg. Excipients: Microcrystalline cellulose, magnesium stearate, polyethylene glycol 6000, polymethacrylate, polysorbate, colloidal silica, emulsified silicone, sodium starch glycolate, talc.


5 400-mg bottles of lyophilised powder + 5 phials of solvent solution 20 400-mg tablets of gastro-resistant tablets




Symptoms of depression


Known individual hypersensitivity to the product.


The lyophilised powder must be mixed with the accompanying solvent solution immediately prior to use. The intravenous injection should be carried out very slowly. SAMYR tablets are gastro-resistant, thus releasing the ademetionine in the duodenum. The tablets should not be removed from the blister pack until just prior to use. These should not be chewed but swallowed whole. For better absorption of the main principle and a more through therapeutic effect, SAMYR should be taken between meals.


SAMYR is compatible with any other anti-depressant treatments, particularly tricyclens and monoaminoxidase inhibitors. Taking ademetionine does not cause negative interactions with alcohol.


Effects on the capacity to drive or use machinery. Does not interfere with the capacity to drive vehicles or to operate machinery.


Ampoules: 1 bottle per day for a 15-20 day cycle, to be taken intravenously or intramuscularly. Tablets: 2-3 tablets per day according to your doctor's prescription. The treatment can be initiated parenterally (one bottle per day intravenously or intramuscularly for 15-20 days) and continued orally (2-3 tablets per day). Overdose: Cases of overdose are practically unknown.


Significant side effects have not been seen, not even over long periods of treatment or with a high dosage. Nor have cases been reported of habit formation or drug-dependence. Ademetionine can be taken safely during pregnancy, by the elderly and by those with chronic hepatic problems. SAMYR has been known to cause rare disturbances in the sleep rhythms of hypersensitive patients. Should this occur, a sleeping medication (hypnotic) might be useful. Given the acid pH, which for stabilising reasons is maintained in the active principle in the tablets, cases have been reported of heartburn and a sense of epigastric heaviness by patients who have taken this product orally. However, such episodes are of short duration and should not warrant stopping the treatment. If at any time the patient should note any adverse effects other than the above he should consult his doctor.


See the expiry date shown on the box. This applies to the product properly stored and packaged. Warning: Do not use this product after the expiry date printed on the box. Keep SAMYR away from sources of heat. Should the lyophilised powder take on a colour other than its original white, owing to breakage of the bottle or exposure to heat, return the product in its entirety to your chemist and have it exchanged.


See Figure 1 and Figure 2 : DIRECTIONS FOR OPENING: Position the phial as shown in Figure 1. Press down on the coloured dot with the thumb, as shown in Figure 2.

The above information is the translation of the manufacturer's insert. It is provided under the supplying company's terms and conditions and should not replace the advice of your personal physician.

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