Energy generating formulas for dermatitis and skin-aging

Written by IONESCU, Ph.D., John

Professor John Ionescu is one of Europe’s leading dermatologists. His work which is undertaken at his clinic near Munich, Germany is proving that all skin diseases and disorders are the result of toxins or allergies. In children these can often be traced back to the mother. In this article, Dr. Ionescu gives an insight into one of his remarkable new products; Energy ® cream, which has been specifically used to treat people with skin problems such as psoriasis and eczema etc.

Premature skin aging is strongly related to an impaired cellular energetic metabolism. This leads in turn to reduced DNA and wound repair capacity, followed by skin atrophy with low replication rate in all skin layers.

On the other hand, inflammatory and proliferating skin conditions like acne and psoriasis are associated with decreased cyclic nucleotides, like cAMP in blood and epidermal cells. (1) With the knowledge of these facts, the correction of the cellular energetic metabolism, by means of energy generating compounds is a prerequisite for successful integrative treatment. Research conducted at the Spezialklinik in Neukirchen, Germany, has led to a new skin formulation, known as Energy ® cream. It was originally used for clinical conditions like psoriasis, acne, seborrhoic eczema and burns.

Psoriasis is a well-known inflammatory skin disease associated with erythema, development of scales, vesicles and an accelerated growth of the epidermis. Besides the genetic disposition, additional provocations include:

  • Chemical or physical skin irritations, skin injuries, surgical interventions
  • Negative climate changes, (damp and cold weather, sunburn)
  • Long-term intake of drugs, (for example, beta-blockers, lithium salts, penicillin, sulfonamides, anti-malaria-drugs etc)
  • Bacterial or mycotic infections of the skin, lungs or intestinal tract, as superantigen triggers
  • Cytokine misbalance related to changes in the humoral and cellular immune function
  • Consumption of specific foods and food supplements, increasing the skin irritation by IgE-mediated or pseudoallergic reactions
  • Toxins like pesticides, fertilizers, wood preservatives, solvents, cosmetic ingredients or heavy metals from dental alloys, triggering the keratocyte proliferation via activated T-lymphocytes
  • An impaired energetic metabolism associated with low concentrations of energy rich compounds (ATP) and cyclic nucleotides (cAMP), related to the increased epidermal proliferation rate
  • A misbalanced purine, protein and polyunsaturated fat metabolism
  • A decreased antitoxic function of liver and blood cells
  • Neurohormonal disturbances expressed by significant variations of catecholamines and suppression of ?-adrenoreceptors
  • Significantly increased free radical levels in whole blood and deviations of the plasma and serum redox potentials
  • Negative psychogenic factors like conflict situations, examination anxiety, loss of job, accidents, operations, divorce, death of relatives etc

All of the above can be responsible for the outbreak of psoriasis. (2)

German doctors noticed in the late 80’s that psoriatic skin lesions significantly responded to supplementation with energy generating compounds like ATP, ADP, AMP as well as coenzymes of the energetic metabolism like nicotinamide, NAD and NADP.

As the Energy ® cream with its pure biological ingredients, boosts the cell activity and stimulates the energy metabolism by its ATP precursors (nicotinamide and AMP), it has proven to be very useful in the therapeutic and post-therapeutic skin care of psoriasis patients, by eliminating erythem and normalizing the cell replication rate. (3)

Another study was undertaken involving with 20 psoriasis patients in the Dermatology Clinic of the Bucharest Military Hospital. The research suggested that Energy ® cream is effective in the maintenance therapy of psoriasis, especially following phototherapy, when xerodermia and pruritus appeared. (4)

Inflammatory acne skin conditions are also characterized by a decreased local cellular immune response and low epidermal ATP-levels. In a previous study, 42 acne patients, (19 with slight and 23 with medium forms) used Energy cream for 30 days applied twice daily, (morning and evening, after cleaning the face with cold water). During the treatment patients were advised to avoid spices, food prepared in hot oil, alcohol and smoking. Before being used on face and neck, the irritative and allergic tolerance of the Energy cream was first tested on the forearm skin and was well accepted by all patients.

All 19 patients with slight forms of acne reported a significant decrease in the number of comedones and papulo-pustulas. In the 23 cases with medium forms of acne, the results were evaluated as being favourable, and a definite suppression of sebum secretion was registered. In 8 out of 42 patients, a biological peeling was noticed, which disappeared after 12 to 14 days of treatment. All patients showed a decrease of the skin erythem and inflammation around the acne pustules after 3 weeks of administration. The scar avoidance and the skin smoothing effect of the cream were also greatly appreciated. (5)

When using the Energy cream, scientists at the Spezialklinik Neukirchen, also noticed that successfully treated psoriatic areas of the scalp and forehead skin, demonstrated a significant improvement in skin structure and wrinkles. 33 different test formulations were required to improve the original psoriatic cream to a market conforming cosmetic mixture for rapid skin regeneration with prominent anti-aging effects.

We know today, that the intrinsic (genetically determined) and the extrinsic (UV- and toxic exposure mediated), aging processes are overlapped and strongly related to an increased generation of free radicals, (activated oxygen species) in the skin. This leads in turn to accelerated collagen, elastin and hyaluronic acid degradation, associated with decreased water retention, diminished antioxidant capacity, disrupted cellular structures, low energetic metabolism, sagging and wrinkled skin.

Biomarkers of intrinsic skin aging include hyaluronic acid depolymerisation, the reduced melanogenesis and estrogen dependent collagen synthesis, the lowered ATP generation and wound repair capabilities, the impaired antioxidant defence and increased lipofuscin generation, (age spots).

In accord with the identified aging biomarkers, specific therapies to minimize the intrinsic and the extrinsic skin aging processes were proposed. Besides “classic approaches” for intrinsic aging including topical hyaluronate, estrogens and vitamin C substitution, new interventions addressing the low energetic metabolism and melanin synthesis, (such as energy creams with ATP precursors etc.), were required. (6)

With its optimal combination of essential oils and amino acids, having a restorative effect on cell structures, as well as natural moisturizing and energetic factors with their smoothing and activating effect, the Energy cream is absorbed immediately into the skin, and does not leave a greasy feeling when applied. It protects the skin and activates the cells with its micro-molecular components and energy generating ingredients. Of special interest is the melanin promoting effect of phenylalanine, which leads to a rapid tanning process, with solar protection.

The hypoallergenic cream is free of preservatives, colors and fragrances and therefore suitable for sensitive or allergic skin. The result is healthy, fresh looking skin.

In this respect, the Energy cream is a unique skin care product, which clearly reduces daily skin problems induced by:

  • The aging process
  • Environmental pollutants
  • Lack of moisture
  • Stress
  • Nicotine
  • Alcohol
  • Imbalanced nutrition
  • Insufficient sleep and exercise
  • Long exposure to the sun or to cold

Energy cream is therefore recommended:

  • For women and men of all ages and all skin types
  • As an ideal beauty product for sensitive, flaky, dry, fatty or acned skin
  • For all over permanent care (face, neck, throat and hands)
  • For damaged skin, e.g. burns, cuts etc., (it accelerates the wound repair process)
  • For immediate itching relief after mosquito bites
  • After sports, bathing and after sun exposure
  • For protection against pollution and cold
  • As a man’s after-shave
  • For long term post therapy skin care in chronic dermatological conditions as eczema, psoriasis or acne

When applied, the energy transfer reaction is registered as a warm sensation associated with a rosy, shiny skin colour. This is not an allergic or incompatibility reaction and subsides after 20-30 minutes. After three weeks of regular use, the skin takes on a fresher, healthier look, impurities are eliminated and wrinkles are diminishing.

Energy cream, with its pure biological ingredients, boosts the cell activity and the growth of young cells. It increases the microcirculation of the skin surface, the production of melanin and stimulates the energy metabolism by its ATP-precursors.

Energy cream has an outstanding restorative, stabilizing and skin smoothing effect. It calms irritated skin which is prone to inflammation, and improves the restoration of the epidermis with its soft peeling effect. Used twice a day, it eliminates impure spots, comedones and oily acne skin, offering a natural moisture and velvety softness.

The multiple indications for this special product therefore recommend it as a “universal aid” cream, as many German, Swiss and Asian patients have already reported.


  1. Kiehl R., Ionescu G.: A defective purinnucleotide synthesis pathway in psoriatic patients. Acta Derm. Venereol. (Stockh.) 72, 253-255, 1992.
  2. Ionescu J.G.: Integrative therapy approaches for psoriasis. Syllabus of the 3rd International Conference on Integrative and Longevity Medicine, p. 113-119, Taiwan, Sept. 1-2, 2001.
  3. Ionescu G.: Psoriasis: Dauerhafte Beschwerdefreiheit. Psoriasis Magazin 6, 9-10, 1987.
  4. Nedelcu I.: Energy Emulsion – Results of the dermato-cosmetic tests. Rev. Med. Militara, 31-34, 1996.
  5. Nedelcu I., Ionescu G.: Energy inducing compounds in the topical treatment of Acne. Poster at the 19th World Congress of Dermatology, June 1997, Sydney, Australia.
  6. Ionescu J.G.: The impact of the free radical theory of aging on skin structure and potential therapies. Proceedings at the 3rd Int. Anti-Aging Conference, Monte Carlo, Monaco, Sept. 6-7, 2002.